Formula D - Mannose is a dietary supplement containing D-mannose monosaccharide.
What is D-Mannose?
D-mannose is a simple sugar, which has a particular contribution to metabolism, through its role in glycosylation of certain proteins. D-mannose is rapidly absorbed and reaches the peripheral organs in about 30 minutes and is then excreted by the urinary tract. It cannot be converted into glycogen, therefore it is not stored in the body. It attaches to lectins and in this way prevents the adhesion of pathogens to the walls of the bladder.
Mechanism of Action
Its mechanism of action is expressed by inhibition of adhesion of the FimH surface protein. With the direct binding of FimH to D-mannose associated with a carrier protein, which is responsible for receptor specificity.
The 1st stage of adhesion includes the mannose-sensitive binding of FimH to the epithelium. The wall of the bladder is coated with various glycosyled proteins with mannose, such as tamm-horsfall protein (THP) which directly interferes with the adhesion of microbes to the mucosa. Tamm-Horsfall protein (THP) can be linked to E. Coli with a special bond, which can be inhibited by exogenous D-mannose.
By inhibiting the adhesion of microbes to the urinary tract epithelium, D-mannose mimics the function of the epithelial barrier of the urinary tract.